Electrophysiological & Sleep Abnormalities in Angelman Syndrome
Time: 12:10 pm
day: Day Two
Details:
- Awake EEG delta-band activity correlates with symptom severity crosssectional and longitudinally
- The observational study FREESIAS investigated sleep in AS and controls
over the course of one year by a multi-modal approach - Sleep diary reveals sleep impairment in AS compared to controls,
especially visible in variability of sleep over time. - Sleep mat provides daily, effortless and objective sleep metrics that
correlate well with parent reports (e.g. sleep diary, SNAKE) - Although sleep scoring is complicated by the high delta-band
activity observed in Angelman syndrome, overnight PSG recordings
reveals abnormal sleep physiology with high between-patient
variability
