Electrophysiological & Sleep Abnormalities in Angelman Syndrome

Time: 12:10 pm
day: Day Two


  • Awake EEG delta-band activity correlates with symptom severity crosssectional and longitudinally
  • The observational study FREESIAS investigated sleep in AS and controls
    over the course of one year by a multi-modal approach
  • Sleep diary reveals sleep impairment in AS compared to controls,
    especially visible in variability of sleep over time.
  • Sleep mat provides daily, effortless and objective sleep metrics that
    correlate well with parent reports (e.g. sleep diary, SNAKE)
  • Although sleep scoring is complicated by the high delta-band
    activity observed in Angelman syndrome, overnight PSG recordings
    reveals abnormal sleep physiology with high between-patient