EEG as a Translational Biomarker for Angelman Syndrome

Time: 3:30 pm
day: Day One

Details:

• Slow-wave delta EEG activity is an objective measure of neuronal function which reflects clinical severity in Angelman Syndrome

• A mouse model of Angelman syndrome also shows abnormal slow-wave oscillations which can be corrected after treatment with an ASO which increases Ube3a protein

• EEG acquisition and analyses are being optimized for use in interventional trials as a potential early indicator of therapeutic efficacy

Speakers: